Paowarin Khayaiwong

Research Projects

• Targeting low ADC regions for radiotherapy treatment of glioblastoma on an MR-Linac active

  Glioblastoma (GBM) is an aggressive brain tumour with a poor prognosis and low overall survival despite advances in medical treatment. As GBM remains incurable, current treatments may modestly prolong survival; however, in-field tumour recurrence during or after radiotherapy remains a major clinical challenge. Monitoring tumour progression during treatment is therefore essential. The emergence of Magnetic Resonance Imaging-Linear Accelerator (MRI-Linac) systems, which integrate diagnostic MRI with a linear accelerator, enables daily imaging and adaptive radiotherapy. The apparent diffusion coefficient (ADC), derived from MRI images acquired on MRI-Linac systems, is a crucial imaging biomarker for predicting tumour response. Changes in ADC during radiotherapy have been associated with tumour response and recurrence in GBM. This study focuses on low-ADC regions, as temporal ADC changes during treatment may correlate with tumour response. Low-ADC regions may therefore serve as suitable targets for dose-escalated adaptive radiotherapy using MRI-Linac systems.